MersV1, Main, Exploration, bibRecord, 000717

A53 MERS-CoV in East African dromedary camels

Identifieur interne : 000717 ( Main/Exploration ); précédent : 000716; suivant : 000718

A53 MERS-CoV in East African dromedary camels

Auteurs : Ziqi Zhou [République populaire de Chine] ; Daniel K W. Chu [République populaire de Chine] ; Abraham Ali [Éthiopie] ; Getnet F. Demissié [Éthiopie] ; Malik Peiris [Éthiopie]

Source :

Virus Evolution [ 2057-1577 ] ; 2019.

RBID : PMC:6736029

Abstract

Human Middle East respiratory syndrome is a zoonotic respiratory disease caused by Middle East respiratory syndrome coronavirus (MERS-CoV) originating from camels in the Arabian Peninsula. While there are a large number of camels in East Africa, often traded to the Arabian Peninsula, no autochthonous human MERS-CoV case is reported in East Africa. Furthermore, there is limited information of MERS-CoV in East Africa. In this study, MERS-CoV in dromedary camels from Ethiopia was detected using RT-qPCR. Next-generation sequencing was used to obtain the full genome of MERS-CoV. MERS-CoV antibodies were also detected through MERS-spike pseudoparticle neutralization assay. Phylogenetic analysis of full-genome sequences and spike-genome antibodies indicates that MERS-CoV in East Africa is genetically distinct from those in the Arabian Peninsula. The results from this study show that MERS-CoV circulating in dromedary camels in East Africa are genetically distinct from those in the Arabian Peninsula. Further studies are needed to evaluate the risk of zoonotic transmission in East Africa.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736029

DOI: 10.1093/ve/vez002.052
PubMed: NONE
PubMed Central: 6736029

Affiliations:

République populaire de Chine, Éthiopie

Le document en format XML

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<p>Human Middle East respiratory syndrome is a zoonotic respiratory disease caused by Middle East respiratory syndrome coronavirus (MERS-CoV) originating from camels in the Arabian Peninsula. While there are a large number of camels in East Africa, often traded to the Arabian Peninsula, no autochthonous human MERS-CoV case is reported in East Africa. Furthermore, there is limited information of MERS-CoV in East Africa. In this study, MERS-CoV in dromedary camels from Ethiopia was detected using RT-qPCR. Next-generation sequencing was used to obtain the full genome of MERS-CoV. MERS-CoV antibodies were also detected through MERS-spike pseudoparticle neutralization assay. Phylogenetic analysis of full-genome sequences and spike-genome antibodies indicates that MERS-CoV in East Africa is genetically distinct from those in the Arabian Peninsula. The results from this study show that MERS-CoV circulating in dromedary camels in East Africa are genetically distinct from those in the Arabian Peninsula. Further studies are needed to evaluate the risk of zoonotic transmission in East Africa.</p>
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A53 MERS-CoV in East African dromedary camels

A53 MERS-CoV in East African dromedary camels

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Abstract

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